Sir Syed College
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Research

About the Center

The Department of Chemistry was established in 1967. The Chemistry Post Graduate course was started in 2001. A Research Centre in Chemistry was established in the College in 2008, with a view to promote research interests, both among the students and the teachers of the Department. Currently the Department offers Under-Graduate courses, Post- Graduate courses and research programmes. The Department is an approved research centre for Chemistry under Kannur University. The Research Department is engaged in active research and conducts various research activities in the fields of computational chemistry, synthetic organic chemistry and inorganic chemistry. so far 9 Scholars from the department have been awarded PhD under different Supervisors. The department has eight faculty members, out of whom 3 are research guides.

Research Facilities

Magnetic stirrer

A magnetic stirrer is a commonly used laboratory instrument designed for stirring liquids in various research and scientific applications. It consists of a flat or cylindrical platform containing a magnetic stir bar, typically made of Teflon-coated magnet

Research lab

Our research lab is at the forefront of innovation, dedicated to exploring and advancing the frontiers of chemical science. Comprising a dynamic team of accomplished researchers, graduate students, and faculty members, our lab focuses on a diverse array o

Computational Chemistry Lab

Applying new software and hardware capabilities for data collection and analysis. Developing computer models and simulations of chemical and biochemical processes and entities. Performing and interpreting statistical analysis of large datasets.

FT-IR Spectrophotometer

FT-IR (Fourier Transform Infrared) Spectroscopy is a powerful analytical technique used in chemistry to study molecular vibrations. It identifies functional groups in a sample by measuring its unique infrared absorption patterns, providing valuable insigh

Research Supervisors
Dr. Fazal Edakot

Assistant Professor

Dr. Ashwani Kumar N

Assistant Professor

Dr. Fasila PM

Assistant Professor

Research Publications
Sl.No. Author Details Year Link
1 Dr. Biju A. R Megha P Nambiar1 & Sarayu Jayadevan1 & BK Babu2 & AR Biju1 *, Computational studies on the structural variations of MAO-A and MAO-B inhibitors - An in silico docking approach, Indian Journal of Biochemistry & Biophysics Vol. 59, March 2022, pp. 276-295. 2022
2 Ms. Sarayu Jayadevan T. P. Nafeesa Baby, V. Vineethkumar1, K. P. Shimod2, C. V. Vishnu3, Sarayu Jayadevan4, T. P. Nafeesa Baby, V. Vineethkumar1, K. P. Shimod2, C. V. Vishnu3, Sarayu Jayadevan4, Radiation protection and environment45(1)54-61 2022
3 Dr. Biju, A. R and Dr. Ashwanikumar, Nambiar, M. P.; Ashwanikumar, N.; Anoop, A.; Biju, A. R, Binding energy analysis and molecular dynamic simulation studies of the designed orally active, non-toxic GABARAP modulators, Journal of biomolecular Structure & Dynamics 41(69):1-19 2022
4 Dr. Biju, A. R Megha P Nambiar & Biju AR*, Designing of promising Tromethamine-Diflunisal-Pyrrole combinations based on COX binding, drug-properties and safety, Designing of promising Tromethamine-Diflunisal-Pyrrole combinations based on COX binding, drug-properties and safety, 2022
5 Dr. Fasila P. M Varsha Lisa John1 , Fasila P M2 , Chaithra K P1 and Vinod T P1, Carbon dots derived from frankincense soot for ratiometric and colorimetric detection of lead (II), Nanotechnology 33 (2022) 495706 (10pp). 2022
6 Dr. Rajeena Pathoor Aranhikkal Shamsiya, Rajeena Pathoor, D. Bahulayan, Indole/oxazolone functionalized coumarins as pH-sensitive fluorescent kinase inhibitors, Tetrahedron Letters. 2022,101 2022
7 Dr. Zeinul Hukuman M. Jisha 1 , N. H. Zeinul Hukuman 1 , P. Leena 1,2 and V. P. Nair 3*, Antioxidant, Antimicrobial, Anticorrosion and Molecular docking studies on Alpinia calcarata Rosc., rhizome and leaf extracts, J. Mater. Environ. Sci., 2021, Volume 12, Issue 02, Page 244-270 2021
8 Dr. Fasila P. M and Dr. Biju A. R Rahana Ameen a, c, Fasila P. M c, Anakuthil Anoop b, Biju A. R c, *, Detonation properties and impact sensitivities of trinitromethane derivatives of three-membered heterocyclic ring compounds , Journal of Molecular Graphics and Modelling 105 (2021) 107863 2021
9 Dr. Fasila P. M and Dr. Biju A. R Rahana Ameen a,b, P.M. Fasila b, A.R. Biju b,*, Theoretical studies of azete based high energy density materials with trinitromethane functional group, Computational and Theoretical Chemistry 1203 (2021) 113346 2021
10 Dr. Fasila P. M and Dr. Biju A. R P.M. Fasila a, Ameen Rahana a,b, A.R. Biju a,*, Theoretical investigation of energetic performance and impact sensitivities of nitro and trinitromethyl substituted ozonides of ethylene and cyclopentene, Computational and Theoretical Chemistry 1205 (2021) 113425. 2021
11 Dr. Ashwanikumar Siddharth Patel1, N. Ashwanikumar1, Ema Robinson1, Yan Xia2, Cosmin Mihai2, Joseph P. Griffith III3, Shangguo Hou 3, Adam A. Esposito2, Tatiana Ketova2, Kevin Welsher 3, John L. Joyal2, Örn Almarsson2 & Gaurav Sahay1,4*, Naturally-occurring cholesterol analogues in lipid nanoparticles induce polymorphic shape and enhance intracellular delivery of mRNA, NATURE COMMUNICATIONS | https://doi.org/10.1038/s41467-020-14527-2 2020
12 Dr. Biju. A. R Reena1, Dr. Biju. A. R2, Megha P Nambiar3, Synthesis Characterisation and Application of Manganese Complex with Dafone and Methanol ,IJRASET) ISSN: 2321-9653; IC Value: 45.98; SJ Impact Factor: 7.429 Volume 8 Issue III Mar 2020 2020
13 Dr. Biju.A.R Dr. Biju. A. R, Synthesis Characterisation and Application of Copper Complexes with N-(4-pyridyl) isonicotinamide, 2020 IJRAR March 2020, Volume 7, Issue 1 2020
14 Dr. Biju A. R Reena*1 and Dr. Biju A. R.2, Synthesis and antimicrobial studies of manganese complexes with ortho vaniline oxime and substituted benzoic acid, wjpmr, 2020,6(5), 216-220 2020
15 Dr. Zeinul Hukuman N. H.and Dr. A. R. Biju1 Palakkal Leena1,2*, Zeinul Hukuman N. H.1 , A. R. Biju1 , and Mullapally Jisha1, Studies on Methanolic Extract of Lepidagathis keralensis as Green Corrosion Inhibitor for Mild Steel in 1M HCl, J. Electrochem. Sci. Technol., 2019, 10(2), 231-243 2019
16 Dr. Zeinul Hukuman N.H M. Jisha1*, N. H. Zeinul Hukuman1, P. Leena1, 2 and A. K.Abdussalam3, Electrochemical, computational and adsorption studies of leaf and floral extracts of Pogostemon quadrifolius (Benth.) as corrosion inhibitor for mild steel in hydrochloric acid, J. Mater. Environ. Sci., 2019, Volume 10, Issue 9, Page 840-853 2019
17 Dr. Zeinul Hukuman N.H Palakkal Leena1,2*, Zeinul Hukuman N.H.1 and Mullapally Jisha1, Corrosion inhibition properties of the extracts of Hemigraphis colorata against mild steel in acidic media ,Vol. 23 (6) June (2019) Res. J. Chem. Environ. 2019
18 Dr. Ashwani Kumar S. Meenu Vasudevan,a,b N. Ashwanikumarc and G. S. Vinod Kumar *a, Peptide decorated glycolipid nanomicelles for drug delivery across the blood–brain barrier (BBB)† , Biomaterials Science 2019
19 Dr. Ashwanikumar Jeonghwan Kim1, Ashwanikumar Narayana1, Siddharth Patel1, Gaurav Sahay 1,2, Advances in intracellular delivery through supramolecular self-assembly of oligonucleotides and peptides ,Theranostics 2019, Vol. 9, Issue 11 2019
20 Dr. Rajeena Pathoor Rajeena Pathoor, P Thasnim and D Bahulayan.,“An efficient green diversity-oriented synthesis of Pyrimidinone and Indole appended macrocyclic peptidomimetics”., Tetrahedron Letters. 2019, 60, 191-196 2019
21 Dr. Zeinul Hukuman N. H.and Dr. A. R. Biju1, Palakkal Leena1,2*, Zeinul Hukuman N. H.1, A. R. Biju1, and Mullapally Jisha1, Studies on Methanolic Extract of Lepidagathis keralensis as Green Corrosion Inhibitor for Mild Steel in 1M HCl , J. Electrochem. Sci. Technol., 2019, 10(2), 231-243 2018
22 Dr. Zeinul Hukuman Jisha M¹*, Zeinul Hukuman N. H¹, Leena.P¹ , Corrosion inhibition and absorption studies of pogostemon-quadrifolius methanolic stem extract (PQMSE) on mild steel in 1M HCL, International Journal of Advanced Chemistry, 6 (2) (2018) 157-162 2018
23 Dr. Rajeena Pathoor Rajeena Pathoor and D Bahulayan, “MCR-click synthesis, molecular docking and cytotoxicity evaluation of a new series of indole–triazole–coumarin hybrid peptidomimetics”, ” New Journal of Chemistry. 2018, 42. 6810-6816 2018
24 Dr. Ashwanikumar N Ashwanikumar, Justin S. Plaut, Barmak Mostofian, Siddharth Patel, Peter Kwak, Conroy Sun, Kerry McPhail, Daniel M. Zuckerman, Sadik C. Esener, Gaurav Sahay. “Supramolecular self assembly of nanodrill-like structures for intracellular delivery” Journal of Controlled Release. 2018, 282, 76-89. (Impact factor = 11.47). ISSN 0168-3659 2018
25 Dr. Zeinul Hukuman Leena Palakkal*, N. H. Zeinul Hukuman, Jisha Mullappally, Antioxidant activities and chemical composition of various crude extracts of Lepidagathis keralensis, Journal of Applied Pharmaceutical Science Vol. 7 (06), pp. 182-189, June, 2017 2017
26 Dr. Zeinul Hukuman NH Jisha M*, Zeinul Hukuman NH , In Vitro Antioxidant Efficacy of the Flowers and Leaves of Pogostemon quadrifolius (Benth.) F. Muell. (Lamiaceae), Der Pharma Chemica, 2017, 9(8):21-24 2017
27 Dr. Fazal Edakot FT-IR, FT-Raman and NMR characterization of 2-isopropyl-5-methylcyclohexyl quinoline-2-carboxylate and investigation of its reactive and optoelectronic properties by molecular dynamic simulations and DFT calculations. Vidya V.Menon, Edakot Fazal, Y.Sheena Mary, C.Yohannan Panicker, Steven Armacovic Subban Nagarajand,C .Van Alsenoy. Journal of MolecularStructure., 2017.1127.,124-137. 2017
28 Dr. Ashwanikumar Siddharth Patel, N Ashwanikumar, Emily Robinson, Allison DuRoss, Conroy Sun, Kerry Benenato, Cosmin Mihai, Örn Almarsson, Gaurav Sahay "Boosting intracellular delivery of lipid nanoparticle encapsulated messenger RNA” Nano Letters. 2017, 17 (9), 5711- 5718. (Impact factor = 12.26). ISSN 1530-6984 2017
29 Dr. Rajeena Pathoor Rajeena Pathoor and D Bahulayan,Synthesis of large Stokes shift and narrow emission indole– triazole–carboxamide peptidomimetics via MCR-click strategy”, Tetrahedron Letters.2016, 57. 2360-2366. 2016
30 Dr. Fazal Edakot Synthesis, Spectroscopic analysis and molecular docking studies of 4-chloro-3-methylphenyl quinoline-2-carboxylate. Fazal Edakot, Shana Parveen S, Monirah A.Alshaikh, C.Yohannan Panickerc, Ali A. El-Emam, Subban Nagarajand, C., Science Letters Journal., 2016.,5.237. 2016
31 Dr. Fazal Edakot Synthesis, FT-IR, FT-Raman, NMR spectra and molecular docking study of 2-methoxyphenyl quinoline-2-carboxylate. Fazal Edakot, Shana Parveen S, C.Yohannan Panickerc, Subban Nagarajand, C.Van Alsenoy. Science Advances Today., 2016.,2.,25232 2016
32 Dr. Ashwanikumar N. Ashwanikumar, Nisha Asok Kumar, P.S. Saneesh Babu, K.C. Sivakumar, Mithun V Varghese, Parvathi Nair, I. Hema Saranya, S. Asha Nair, G.S. Vinod Kumar “Self assembling peptide nanofibrous scaffold containing phenylalanine for the controlled delivery of 5-fluorouracil” , International Journal of Nanomedicine, 2016, 11:5583-5594. (Impact factor = 7.033). ISSN: 1178-2013. 2016
33 Dr. Fazal Edakot Vibrational Spectroscopic and molecular docking study of 4-Methylphenylquinoline-2-carboxylate. E. Fazal, C. YohannanPanicker, H.T. Varghese, S. Nagarajan, B.S. Sudha. Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy., 2015, 143,213-222 2015
34 Dr. Fazal Edakot Spectroscopic investigation (FT-IR, FT-Raman), HOMO-LUMO, NBO analysis and molecular docking study of 4-chlorophenyl quinoline-2-carboxylate.E. Fazal, C. YohannanPanicker, H.T. Varghese, S. Nagarajan, B.S. Sudha. Spectrochimica Acta Part A:Molecular and Biomolecular Spectroscopy 2015,145,260-269. 2015
35 Dr. Fazal Edakot Synthesis, Crystal and Molecular Structure Studies and DFT Calculations of Phenyl Quinoline-2-Carboxylate and 2-Methoxyphenyl Quinoline-2-Carboxylate; Two New Quinoline-2 Carboxylic Derivatives. Edakot Fazal , Jerry P. Jasinski , Brian J. Anderson , Manpreet Kaur , SubbanNagarajanand BelgurSatyanarayanaSudha.Crystals, 2015, 5, 100-115 2015
36 Dr. Fazal Edakot Microwave assisted synthesis and biological evaluation of potential quinoline-2-carboxylates of aromatic compounds. Edakot Fazal, Pushpa S Murthy, Kamatham A Naidu, AnkisettyMaheshwaraiah, SubbanNagarajan, Belgur S Sudha. Indo American Journal of Pharmaceutical Research, 2015, 5, 02: 625-634 2015
37 Dr. Ashwanikumar Jisha J Pillai, A.K.Thulasidasan, R.J.Anto, N.C.Devika, N.Ashwanikumar, and GSV. Kumar “Curcumin entrapped folic acid conjugated PLGA–PEG nanoparticles exhibit enhanced anticancer activity by site specific delivery” RSC Advances, 2015, 5, 25518– 25524. (Impact factor = 4.036). ISSN 2046-2069 2015
38 Dr. Fazal Edakot Crystal structure of 2,5-Dimethylphenyl quinoline-2-carboxylate.Fazal, E.; Kaur, M.; Sudha, B. S.; Nagarajan, S.; Jasinski, J. P. ActaCryst. 2014. E70, o147. 2014
39 Dr. Fazal Edakot Crystal structure of 3,4-Dimethylphenyl quinoline-2-carboxylate. Fazal, E.; Kaur, M.; Sudha, B. S.; Nagarajan, S.; Jasinski, J. P.ActaCryst. 2014. E69, o1853-o1854. 2014
40 Dr. Ashwanikumar N Ashwanikumar, N.A.Kumar, S.A.Nair, G.S Vinod Kumar “5-Fluorouracil - lipid conjugate: Potential candidate for the drug delivery through encapsulation in hydrophobic polyester based nanoparticles” Acta Biomaterialia. 2014, 10, 4685-4694 (Impact factor = 10.63). ISSN: 1742-7061 2014
41 Dr. Ashwanikumar N Ashwanikumar, N.A.Kumar, S.A.Nair,G.S Vinod Kumar “Dual drug delivery of 5-Fluorouracil (5-FU) and Methotrexate (MTX) through random copolymeric nanomicelles of PLGA and Polyethylenimine demonstrates enhanced cell uptake and cytoxicity in-vitro” Colloids and Surfaces B: Biointerfaces. 2014, 122,520-528. (Impact factor = 5.999). ISSN: 0927-7765 2014
42 Dr. Ashwanikumar N Ashwanikumar, N.A.Kumar, S.A.Nair,, G.S Vinod Kumar “Phenylalanine containing self assembling peptide nanofibrous hydrogel for the controlled release of 5-fluorouracil and leucovorin” RSC Advances, 2014, 4, 29157–29164. (Impact factor = 4.036). ISSN 2046-2069 2014
43 Dr. Ashwanikumar J.J.Pillai, A.K.Thulasidasan, R.J.Anto, N.C.Devika, N.Ashwanikumar, and GSV. Kumar “Folic acid conjugated cross-linked acrylic polymer (FA-CLAP) hydrogel for site specific delivery of hydrophobic drugs to cancer cells” Journal of Nanobiotechnology, 2014, 12, 25-33 (Featured as Highly accessed article). (Impact factor = 9.429). ISSN:1477-3155 2014
44 Dr. Fazal Edakot Crystal structure of 2-Isopropyl-5-methylcyclohexyl quinoline-2-carboxylate. Fazal, E.; Jasinski, J. P.; Anderson.B.J.;Sudha, B. S.; Nagarajan. ActaCryst. 2013. E70, o35-o36. 2013
45 Dr. Fazal Edakot Crystal structure of 4-Chlorophenyl quinoline-2-carboxylate. Fazal, E.; Kaur, M.; Sudha, B. S.; Nagarajan, S.; Jasinski.ActaCryst. 2013. E69, o1841. 2013
46 Dr. Fazal Edakot Crystal structure of 4-Chloro-3-methylphenyl quinoline-2-carboxylate.Fazal, E.; Kaur, M.; Sudha, B. S.; Nagarajan, S.; Jasinski, J. P. ActaCryst 2013. E69, o1842-o1843. 2013
47 Dr. Ashwanikumar N Ashwanikumar, N.A.Kumar, S.A.Nair,G.S Vinod Kumar , “Methacrylic-based nanogels for the pH-sensitive delivery of 5- Fluorouracil in the colon” International Journal of Nanomedicine, 2012;7, 5769 – 5779. (Impact factor = 7.033). ISSN: 1178- 2013. (Featured as Highly accessed article) 2013
48 Dr. Fazal Edakot Crystal structure of 4-Methylphenyl quinoline-2-carboxylate.Fazal, E.; Jasinski, J. P.; Krauss, S. T.; Sudha, B. S.; Yathirajan.ActaCryst.2012. E68, o3231-o3232. 2012
49 Dr. Ashwanikumar Deepa.G, N.Ashwanikumar, J.J.Pillai, GSV Kumar, “Polymer Nanoparticles – A Novel Strategy for Administration of Paclitaxel in Cancer Chemotherapy”, Current Medicinal Chemistry, 2012;19, 6207-6213. (Impact factor = 4.740). ISSN:1875-533X (Online) ISSN: 0929-8673 (Print) 2012
Research Scholars
Sl.No. Name Specialization Supervisor Mode Status
1 Shahabanu P Chemical investigation and evaluation of cardamom (elettaria cardamomum) qualities of authentic and Dr. Fazal E Part Time Ongoing
2 Shruthi K P Theoretical and Computational Investigation of Antiviral Drugs Dr. Ashwani Kumar N Part Time Ongoing
PhD Awardees
Sl.No. Name Supervisor Topic Year
1 Dr. Praveena K. Dr. Zeinul Hukuman Computational study of enolates in organic and biochemical reactions 2013
2 Dr. Bindu P. Nair Dr. Zeinul Hukuman Quinone and pyranone with aromatic systems as potential nanomechanical devices: A computational study 2014
3 Dr. Anjana John Dr. Zeinul Hukuman Studies on the chemistry of incorporation and controlled release of cardiovascular drugs using natural gums 2016
4 Dr. Leena P Dr. Zeinul Hukuman Corrosion Inhibition, Antioxidant and Antimicrobial studies of selected plants belonging to Acanthaceae 2020
5 Dr. Jisha M Dr. Biju A R Phytochemical Studies of Certain Selected Plants with Antimicrobial Properties 2020
6 Dr. Rahana Ameen Dr. Biju A R Detonation properties and impact sensitivities of some heterocyclic compounds. 2022
7 Dr. Fasila P M Dr. Fasila P M Detonation properties of promising high energy materials 2022
8 Dr. Reena Dr. Biju A R Synthesis, characterization and computational studies of transition metal complexes 2022
9 Dr. Megha P Nambiar Dr. Biju A R Experimental and theoretical analysis of molecular structures of selective drug molecules 2023
Seminars/Workshops
Sl.No. Year Type Funding Agency Level Title
1 2020 International Department fund Webinar 2 International webinar DOCTRINA-05 26.05.2020
2 2020 International Department fund Webinar 3 International webinar DOCTRINA-13, 04.06.2020
3 2018 National KSCSTE Seminar One day National Seminar on Frontiers in Inorganic Chemistry , 1 One day National Seminar on Frontiers in Inorganic Chemistry KSCSTE 20.03.2018
Research Projects
Sl.No. Faculty Type Funding Agency Grants Status
1 Dr. Zeinul Hukman Minor UGC Computational chemistry of Keto enol tautomers Completed
2 Dr Zeinul Hukman N H Minor UGC Computational chemistry of keto enol tautomers Completed
3 Dr Mohamed Asraf V Minor UGC Computational chemistry of metal enolates Completed
4 Dr Biju A R Minor UGC Supramolecular studies of biologically active metal complexes Completed